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Toxicologic Neuropathology

Neuropathologic findings in preclinical safety studies are a common reason for delaying the start or decreasing the pace of human clinical trials. Neuropathology is a focused sub-discipline of toxicologic pathology in that proficient practitioners must have wide-ranging expertise in comparative anatomy, chemistry, functional testing, and pathology of the central nervous system as well as the somatic and autonomic divisions of the peripheral nervous system.

Such detailed understanding is especially vital for devising appropriate preclinical study designs, performing neuropathology peer reviews, and differentiating genuine test item-related changes from incidental background lesions. Pathology Experts advisors with expertise in this specialized field can provide substantial value in discovering and developing new biomedical products.